Yijing Decoction improves premature ovarian failure in rats by activating VEGF/VEGFR-2/FAK pathway.

ABSTRACT:

Background

Premature ovarian failure (POF) is defined as amenorrhea that occurs before the age of 40 when the ovaries weaken or even fail. This disease seriously affects a woman's future health and fertility.

Methods

Potential targets of Yijing Decoction (YJD) and POF were predicted by web-based pharmacology-related databases. The POF rat models and human ovarian granulosa cells injury models were induced by triptolide. In addition, the estrous cycle of the rats was monitored by vaginal smear and the ovarian tissue morphology was stained by HE staining. Immunohistochemistry, qRT-PCR and Western blotting were used to evaluate the levels of reproductive and angiogenesis related factors. Moreover, serum levels of the sex hormones and the oxidative stress indicators were measure

SUBMITTER: Gao R 

PROVIDER: S-EPMC12034217 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature