Sustained caloric restriction potentiates insulin action by activating prostacyclin synthase.

ABSTRACT:

Objective

Caloric restriction (CR) is known to enhance insulin sensitivity and reduce the risk of metabolic disorders; however, its molecular mechanisms are not fully understood. This study aims to elucidate specific proteins and pathways responsible for these benefits.

Methods

We examined adipose tissue from participants in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE 2) study, comparing proteomic profiles from individuals after 12 and 24 months of CR with baseline and an ad libitum group. Biochemical and cell-specific physiological approaches complemented these analyses.

Results

Our data revealed that CR upregulates prostacyclin synthase (PTGIS) in adipose tissue, an enzyme crucial for producing prostacyclin (PGI2).

SUBMITTER: Merali C 

PROVIDER: S-EPMC12034231 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature