Three distinct classes of myenteric ganglia in mice and humans: insights from quantitative analyses.

ABSTRACT:

Background

The myenteric plexus primarily consists of the myenteric ganglia, which include enteric neurons, synaptic neuropils, and glial cells. Abnormal myenteric plexus formation can result in gastrointestinal disorders. Comprehensive morphological classification studies of myenteric ganglia remain limited.

Methods

Whole-mount immunofluorescence staining was used to label myenteric ganglia in colon tissue of mice and children. The ganglionic area and the number of intraganglion neurons were quantified by the K-means clustering algorithm. The guts of embryonic day 11.5 (E11.5) mouse were cultured and immunostained to observe the characteristics of developing myenteric ganglia.

Results

Myenteric ganglia can be categorized into three groups in the colon tissues of mice

SUBMITTER: Wu L 

PROVIDER: S-EPMC12034244 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature