CONSTRUCT: an algorithmic tool for identifying functional or structurally important regions in protein tertiary structure.

ABSTRACT:

Motivation

Evolutionary rates in protein-coding genes vary widely, reflecting functional and/or structural constraints. Essential or highly expressed proteins tend to evolve more slowly, and within a protein, different amino acid sites experience distinct selective pressures. Accurately modeling this variation is critical for identifying functional and/or structurally important amino acid sites. Standard methods assume independent substitution rates across sites, and the most conserved ones are widely distributed in protein tertiary structure. This is biologically unrealistic, as functional sites tend to cluster in 3D space.

Results

Here, we developed CONSTRUCT, an improved strategy for detecting functional and structurally important regions in protein tertiary structure. Gi

SUBMITTER: Chivot L 

PROVIDER: S-EPMC12034385 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature