VirDiG: a <i>de novo</i> transcriptome assembler for coronavirus.

ABSTRACT:

Motivation

The discontinuous transcription mechanism of coronaviruses contributes to their adaptation to different host environments and plays a critical role in their lifecycle. Accurate assembly of coronavirus transcripts is vital for understanding the virus's biological traits and developing precise prevention and treatment strategies. However, existing de novo assembly algorithms are primarily designed for alternative splicing events in eukaryotes and are not suitable for assembling coronavirus transcriptome, which consists of both genomic RNA and subgenomic mRNAs. Coronavirus transcriptome reconstruction from short reads remains a challenging problem.

Results

In this work, we present VirDiG, a de novo transcriptome assembler specifically designed for coron

SUBMITTER: Li M 

PROVIDER: S-EPMC12034387 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature