The Nucleoporin CPR5 Modulates Plant Immunity via Guanylate-Binding Proteins.

ABSTRACT: The nuclear pore complex plays a key role in nuclear transport of immune signals. Two nucleoporins, CONSTITUTIVE EXPRESSION OF PR GENES 5 (CPR5) and GUANYLATE-BINDING PROTEIN-LIKE 3 (GBPL3), have been implicated in plant immunity. The Arabidopsis GBPL family comprises three members. While GBPL1 and GBPL3 were discovered to form an immune circuit, the role of GBPL2 remains unknown. Through genetic screening, we identified a gain-of-function mutation in GBPL2, named suppressor of cpr5 23 (scpr23), that fully suppresses the cpr5 mutant phenotype. The scpr23 function is attributed to a core amino acid residue within a nuclear export signal (NES) motif; its alteration causes a change of GBPL2 localisation from the endoplasmic reticulum to the nuclear envelope. Epistatic analysis demonstrated th

SUBMITTER: Pan L 

PROVIDER: S-EPMC12034427 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature