Diagnostic value of systemic immune-inflammation index and prognostic nutritional index combined with CEA in gastric cancer with lymph node metastasis.

ABSTRACT:

Background

Carcinoembryonic antigen (CEA), systemic immune-inflammation index(SII), and prognostic nutritional index (PNI) are diagnostic markers for cancer, but their combined significance in gastric cancer (GC) with lymph node metastasis remains unclear. The aim of this study was to evaluate the association between these serum biomarkers and lymph node metastasis in patients with GC.

Methods

Records of patients with GC were reviewed retrospectively. Univariate and multivariate logistic regression were performed to examine the association between tumor markers, serum biomarkers and lymph node metastasis in GC. Based on the results of multivariate regression, a nomogram was developed and verified.

Results

Of the 395 patients aged 68.5 ± 9.1 years, 192 (48.6%) were dia

SUBMITTER: Dai XR 

PROVIDER: S-EPMC12034562 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature