Identification of mitochondrial function and programmed cell death associated key biomarkers and the circRNA-miRNA-mRNA regulatory network in systemic lupus erythematosus.

ABSTRACT:

Objectives

Systemic Lupus Erythematosus (SLE) is a highly heterogeneous autoimmune disease with complex pathogenic mechanisms. Mitochondrial function and programmed cell death (PCD) play important roles in SLE. This study aims to screen biomarkers related to mitochondrial function and programmed cell death in SLE and analyze their underlying mechanisms.

Methods

SLE-related databases were derived from the GEO database, where three SLE databases were merged into one database as the training set. Genes related to mitochondrial function and PCD were sourced from the MitoCarta 3.0 database. Key genes were identified through bioinformatics and machine learning, and their expression levels and diagnostic efficacy were validated using two SLE-related datasets as the validation set.

SUBMITTER: Cao J 

PROVIDER: S-EPMC12034568 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature