A pathophysiological and mechanistic review of chronic inflammatory demyelinating polyradiculoneuropathy therapy.

ABSTRACT: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated disease of the peripheral nerves characterized by proximal and distal muscle weakness and sensory abnormalities. CIDP has been associated with various pathophysiological mechanisms that are not fully understood and that likely differ across groups of patients. It has been proposed that an interplay of different immunopathological mechanisms including the cellular, humoral and complement pathways play a key role in peripheral nerve damage in CIDP. Currently approved treatments and therapies in research often target different potential pathophysiological mechanisms. The efficacy of these different treatments can shed light on the prominence of particular pathophysiological pathways in subsets of patients w

SUBMITTER: Caballero-Avila M 

PROVIDER: S-EPMC12034639 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature