Midazolam infusions for therapeutic management of pediatric refractory status epilepticus: a systematic review.

ABSTRACT:

Objective

We aim to determine the optimal dosing of midazolam continuous intravenous infusions for the treatment of pediatric refractory status epilepticus (RSE).

Data sources

We searched Medline ALL, Embase, Embase Classic, Cochrane CENTRAL, and Web of Science in March 2023 and again in February 2024.

Study selection

Randomized and non-randomized studies involving pediatric patients who received continuous midazolam for the treatment of RSE were eligible. Two authors independently conducted screening, full-text review, and data extraction. All methods followed PRISMA reporting guidelines. A narrative data synthesis was performed due to data heterogeneity.

Data extraction and synthesis

Nineteen studies (448 patients) proved eligible; 3 were randomized control t

SUBMITTER: Johnson KT 

PROVIDER: S-EPMC12034653 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature