Evaluation of the immune effect of foot-and-mouth disease virus-like particles derived from <i>Pichia Pastoris</i> on mice and pigs.

ABSTRACT: Foot-and-mouth disease (FMD) is an acute, highly contagious, infectious disease that affects cloven-hoofed animals and the healthy development of animal husbandry. Despite the pivotal role of the inactivated FMD vaccine in preventing and controlling the disease, the production and preparation of the inactivated vaccine still present certain safety concerns. Virus-like particles (VLPs), which have a shell structure similar to that of the viruses but lack the genetic material of viruses, have emerged as a prominent area of research on developing next-generation FMD vaccines. In this study, co-expression of P1 and 3C was implemented to obtain the capsid protein of FMD virus (FMDV), and VLPs of FMD were prepared using Pichia Pastoris. Given that the enzymatic activity of 3C is not ideal

SUBMITTER: Li Z 

PROVIDER: S-EPMC12034696 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature