Characteristics of the pseudorabies virus strain GDWS2 with severe neurological signs and high viral shedding capacity in pigs.

ABSTRACT: Pseudorabies virus (PRV) poses a serious threat to the global swine industry, as PRV infection can lead to reproductive disorders in sows and high mortality in newborn piglets. Although pigs typically exhibit age-related resistance to PRV, with older pigs exhibiting milder symptoms upon infection, the recent isolation of multiple highly pathogenic PRV variants and reports of severe symptoms and even death in older pigs have garnered much attention. The GDWS2 strain isolated in this study exhibits characteristics similar to those of highly pathogenic strains. GDWS2 was isolated from the brain tissue of a 90-day-old diseased pig that exhibited severe respiratory and neurological symptoms. The pig originated from a farm that had been previously vaccinated with the Bartha-k61 strain. In vit

SUBMITTER: Chen W 

PROVIDER: S-EPMC12034708 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature