The role of exosomal lncRNAs in mediating apoptosis and inflammation in UV-induced skin photoaging.

ABSTRACT: The skin, as the body's largest organ, functions as a vital barrier against environmental insults. Chronic exposure to ultraviolet (UV) radiation significantly contributes to premature aging, or photoaging, which leads to DNA damage and disrupts repair mechanisms. Exosomes, which are small extracellular vesicles, play a key role in cell-to-cell communication and might help mitigate the effects of photoaging by transporting bioactive molecules to skin cells. Long non-coding RNAs (lncRNAs) are increasingly recognized for their regulatory roles in the photoaging process, influencing stress responses and DNA repair; however, their involvement in exosomes in the context of skin aging is not yet well understood. In this study, we developed a photoaging model using SD rats subjected to UVA and UV

SUBMITTER: Li K 

PROVIDER: S-EPMC12034729 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature