Spectrophotometric and smartphone-based colorimetric methods utilizing polyvinylpyrrolidone-capped silver nanoparticles for determining doxorubicin in human plasma samples.

ABSTRACT: Doxorubicin (DOX) or adriamycin is a common anticancer drug with a narrow therapeutic index. Therefore, sensitive and reliable quantification of DOX is crucial for therapeutic drug monitoring purposes. In this study, both a spectrophotometric and a smartphone-based colorimetric method were fabricated to detect DOX in plasma samples. Both methods utilize polyvinylpyrrolidone (PVP)-capped silver nanoplates, which undergo color with varying DOX concentrations. The colorimetric method offers significant beneficial features of fast detection time, simplicity, and the ability to be easily observed by the naked eye without any need for expensive instruments. The linear dynamic ranges are 0.25-5.0 µg/mL and 0.5-5.0 µg/mL, with the lower limit of quantification (LLOQ) of 0.25 and 0.5 µg/mL for spec

SUBMITTER: Behboudi E 

PROVIDER: S-EPMC12034750 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature