The biosensor using the target urine volatile organic compounds for detecting diabetic kidney disease.

ABSTRACT: Volatile organic compounds (VOCs) are metabolic byproducts reflecting pathophysiologic processes and have been widely utilized as non-invasive biomarkers for disease differentiation. While VOCs have been extensively studied in oncology, their potential for diagnosing other prevalent public health conditions remains underexplored. This study serves as a proof-of-concept investigation, applying VOC-based detection to diabetic kidney disease (DKD), a leading cause of chronic kidney disease, to distinguish it from other nephrotic syndromes (NS). Utilizing metal oxide semiconductors, we analyzed urinary VOC profiles in 135 participants with biopsy-confirmed diagnoses. All gas sensors in the sensor chamber were of the n-type. Our results demonstrated that hydrogen and ethanol VOCs, measured at a

SUBMITTER: Kreepala C 

PROVIDER: S-EPMC12034762 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature