Long-term systemic androgen deprivation partially modulates neuroinflammation in male App^{NL-G-F/NL-G-F} mice.

ABSTRACT: Alzheimer's disease (AD) is the leading neurodegenerative disease manifesting cognitive impairment. Its procession is regulated by activated glial cell-mediated neuroinflammation. Although estrogen deprivation is a known risk factor for AD in females, the impact of androgen deprivation on AD pathology in males, particularly regarding neuroinflammation, remains unclear. This study investigates the effects of long-term systemic androgen deprivation on AD pathology, including glial cell-specific gene expression, amyloid β (Aβ) pathology, and cognitive function in male castrated App^{NL-G-F/NL-G-F} (App) mice. We found significantly reduced androgen receptor (AR/Ar) expression levels in the precunei of male patients with early AD pathology and isolated brain microglia of male App mice

SUBMITTER: Maekawa K 

PROVIDER: S-EPMC12034793 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature