Exposure to metal mixtures and telomere length in Bangladeshi children.

ABSTRACT: Telomere length is associated with chronic diseases and, in younger populations, may represent a biomarker of disease susceptibility. As growing evidence suggests that environmental factors, including metals, may impact telomere length. We investigated the association between 17 metals measured in toenail samples and leukocyte relative telomere length (RTL), among 472 5- to 7-year-old children enrolled in the Bangladesh Environmental Research in Children's Health (BiRCH) cohortIn single-exposure linear regression models, a doubling of arsenic (As) and mercury (Hg) (μg/g) were associated with a -0.21 (95% CI, -0.032 to -0.010; P = .0005) and -0.017 (95% CI, -0.029 to -0.004; P = .006) difference in RTL, respectively. In Bayesian Kernel Machine Regression (BKMR) mixture models, the overall m

SUBMITTER: Farzan SF 

PROVIDER: S-EPMC12034834 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature