Global analysis of actionable genomic alterations in thyroid cancer and precision-based pharmacogenomic strategies.

ABSTRACT:

Introduction

Thyroid cancer, a prevalent endocrine malignancy, has an age-standardized incidence rate of 9.1 per 100,000 people and a mortality rate of 0.44 per 100,000 as of 2024. Despite significant advances in precision oncology driven by large-scale international consortia, gaps persist in understanding the genomic landscape of thyroid cancer and its impact on therapeutic efficacy across diverse populations.

Methods

To address this gap, we performed comprehensive data mining and in silico analyses to identify pathogenic variants in thyroid cancer driver genes, calculate allele frequencies, and assess deleteriousness scores across global populations, including African, Amish, Ashkenazi Jewish, East and South Asian, Finnish and non-Finnish European, Latino, and Midd

SUBMITTER: Espinoza-Ferrao S 

PROVIDER: S-EPMC12034932 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature