Evaluation of urinary kidney injury molecule-1 in cats with chronic kidney disease.

ABSTRACT: ObjectivesKidney injury molecule 1 (KIM-1) is a transmembrane glycoprotein on proximal renal tubular epithelial cells that is increased in the urine of cats with acute kidney injury. The utility of measuring urine KIM-1 in cats with chronic kidney disease (CKD) and the relationship with International Renal Interest Society (IRIS) stage are unknown. The objectives of this study were to determine the distribution of KIM-1 concentrations in cats with different stages of CKD and investigate the relationship between urine KIM-1 and urine specific gravity (USG), urine protein and serum urea, creatinine, phosphorus, potassium and symmetric dimethylarginine concentrations.MethodsA total of 74 cats with CKD were recruited prospectively from a first-opinion feline-only practice. Blood and urine samp

SUBMITTER: Kornya M 

PROVIDER: S-EPMC12035179 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature