ICOS and ICOS ligand: expression patterns and outcomes in oncology patients.

ABSTRACT:

Background

Inducible T-cell co-stimulator (ICOS) and its ligand (ICOSL) form a complex, two-faced immune machinery that can lead to both immune stimulation and inhibition.

Objective

We explored ICOS transcriptomic expression patterns and their relationship with other checkpoints and with outcomes in patients with advanced/metastatic cancers.

Design

This was a retrospective cohort study.

Methods

RNA expression for ICOS and other immune checkpoints was quantified by RNA sequencing and stratified by rank values into high (75-100 percentiles) and low (0-24 percentiles). Fischer's exact tests were used for univariate analyses to evaluate independent predictors of ICOS high and logistic regression was used for multivariate analyses. Progression-free survival (PFS) an

SUBMITTER: Nikanjam M 

PROVIDER: S-EPMC12035295 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature