Sex differences in brain iron deposition and microglial ferritin in Alzheimer's disease.

ABSTRACT: ObjectiveIron is the most abundant metal in the human brain, and plays a crucial role in many biological processes. However, disruptions in brain iron metabolism can lead to iron buildup, which occurs with aging and is linked to several brain disorders, including Alzheimer's disease. Microglia, the brain's resident immune cells, have the highest capacity to store iron, which is stored intracellularly within ferritin complexes. Importantly, women are at a higher risk of developing Alzheimer's disease and experience faster disease progression compared to men.MethodsWe used postmortem brain samples from patients with Alzheimer's disease and small vessel disease patients of both sexes for immunohistochemical studies. Samples were stained with the Prussian blue method to visualize iron deposits

SUBMITTER: Rahman SM 

PROVIDER: S-EPMC12035364 | biostudies-literature | 2025 Apr-Jun

REPOSITORIES: biostudies-literature