Effectiveness and safety of topical phosphodiesterase 4 inhibitors in children with mild-to-moderate atopic dermatitis: A systematic review and meta-analysis.

ABSTRACT: ObjectiveTo evaluate the efficacy and adverse effects of phosphodiesterase 4 inhibitors in children with mild-to-moderate atopic dermatitis.MethodsElectronic searches were conducted based on PubMed, Cochrane Library, EMBASE, and Web of Science using Medical Subject Headings terms and relevant keywords. Using response rates as the primary outcome and adverse effects as the secondary outcome, statistical analysis was performed via Stata 15.1 SE, with Cochrane Q and I² statistics used for heterogeneity assessment. Publication bias and sensitivity analyses were conducted using various methods. Risk of bias was assessed using the Cochrane risk of bias tool.ResultsThe analysis included six randomized controlled trials involving 4681 children with atopic dermatitis. Phosphodiest

SUBMITTER: Wang L 

PROVIDER: S-EPMC12035403 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature