Outcome measurement instruments in neurodegenerative diseases: Comprehensive analysis and platform construction.

ABSTRACT:

Objectives

The selection of appropriate outcome measurement instruments (OMIs) in neurodegenerative disease (NDD) researches remains complex and often inconsistent. This study aims to consolidate knowledge on OMIs applied in NDD over the last two decades and to develop outcome measurement instruments in neurodegenerative diseases (NDDOMI), a web-based knowledge platform for OMIs selection.

Methods

We collected clinical trials from the past two decades across six prevalent NDDs from ClinicalTrials.gov. OMIs were manually extracted, categorized, and normalized by experts. We analyzed OMI utilization patterns, cross-disease applicability, and temporal trends. Additionally, we developed NDDOMI, a knowledge resource platform, using Django, ECharts, and JavaScript. The usability o

SUBMITTER: Zong H 

PROVIDER: S-EPMC12035495 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature