Effect of cucurbit[7]uril on DPPC-containing liposomes: Interactions with the lipid bilayer.

ABSTRACT: Liposomes, which are bilayer lipidic nanocarriers, have been utilized in many pharmaceutical applications to enhance the solubility and therapeutic index of drugs. Liposomes have also been used as carriers for smaller drug carriers, such as cucurbiturils, to achieve a more controlled release of the drug into the targeted site in the body. In this study, we investigated the effects of cucurbit[7]uril, a macrocyclic organic compound, on the integrity of liposome lipid membranes. The average liposome size, measured by dynamic light scattering, increased with increasing concentrations of cucurbit[7]uril. In addition, fluorescence spectroscopy was used to calculate an association constant (K_a) between cucurbit[7]uril and cholesterol of 3 ×106/M. This high K_a

SUBMITTER: Altaher S 

PROVIDER: S-EPMC12035499 | biostudies-literature | 2025 Apr-Jun

REPOSITORIES: biostudies-literature