Microstructural assessment of the locus coeruleus-entorhinal cortex pathway and association with ATN markers in cognitive impairment.

ABSTRACT:

Introduction

Whether Alzheimer's disease pathology involves white matter pathways connecting the locus coeruleus (LC) to the entorhinal cortex (EC) is unclear. In this cross-sectional observational study, we investigated the microstructural integrity of the LC-EC pathway in relation to amyloid, tau, and neurodegeneration (ATN) biomarkers along the cognitive spectrum from normal cognition to dementia.

Methods

One hundred twenty-four participants underwent clinical assessment, diffusion-weighted imaging, structural magnetic resonance imaging (N), amyloid (A), and tau (T) positron emission tomography. Diffusivity indices were assessed in the LC-EC tract using a probabilistic atlas, and linear models were used to assess associations with ATN markers and cognition.

Results

SUBMITTER: Aiello M 

PROVIDER: S-EPMC12035542 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature