Resilience in Alzheimer's disease: Impact of operationalization and methodological choices.

ABSTRACT:

Introduction

Resilience, the ability to maintain cognition or brain integrity despite Alzheimer's disease (AD) pathology, is often quantified using the residual approach. However, the variability in methodology and correction methods for this approach raises concerns about the interpretability of findings across studies.

Methods

We assessed brain resilience (BR) and cognitive resilience (CR) in a memory clinic population using the residual approach. We compared non-corrected and corrected residuals' associations with risk factors using linear regression models, and their impact on longitudinal cognition using linear mixed-effects models.

Results

Corrected versus non-corrected BR yielded distinct, often opposing, associations. For example, glial fibrillary acidic prote

SUBMITTER: Mutel S 

PROVIDER: S-EPMC12035551 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature