Effects of aged garlic extract on experimental periodontitis in mice.

ABSTRACT: Aged garlic extract (AGE) has been reported to exert anti-inflammatory effects. AGE has been recently found to reduce the inflammatory symptoms of periodontitis, a widespread chronic inflammatory disease caused by oral bacterial infection. However, the mechanisms underlying these effects remain unclear. In the present study, it was aimed to determine the effects of AGE on experimental periodontitis and the related inflammatory factors. AGE (2 g/kg/day) was orally administered to 15 mice during the experimental period, while a control group consisted of 15 mice that received pure water. A total of 3 days after initiation of administration, the left maxillary second molar was ligated with a 5-0 silk thread for 7 days. Blood biochemical tests were performed to monitor the systemic effects of

SUBMITTER: Kuang C 

PROVIDER: S-EPMC12035598 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature