A new paradigm for the regulation of A40926B0 biosynthesis.

ABSTRACT: Dalbavancin is a novel glycopeptide antibiotic with activity against a broad range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). A40926B0 is the direct precursor of dalbavancin, but the regulatory mechanisms underlying its biosynthesis are not well understood. Additionally, the presence of seven homologs leads to significant metabolic burden, affecting both production and purity of A40926B0. To further reveal the transcriptional regulatory mechanism of A40926B0 biosynthesis in N. gerenzanensis L70, this study employed multiple strategies to explore the regulatory network of its biosynthesis from both intracluster and extracluster aspects. WblA regulates gene expression within and outside the biosynthetic gene cluster (BGC), impacting

SUBMITTER: Liu YQ 

PROVIDER: S-EPMC12035728 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature