Cervicovaginal microbiome and natural history of Chlamydia trachomatis in adolescents and young women.

ABSTRACT: This study investigated the cervicovaginal microbiome's (CVM's) impact on Chlamydia trachomatis (CT) infection among Black and Hispanic adolescent and young adult women. A total of 187 women with incident CT were matched to 373 controls, and the CVM was characterized before, during, and after CT infection. The findings highlight that a specific subtype of bacterial vaginosis (BV), identified from 16S rRNA gene reads using the molBV algorithm and community state type (CST) clustering, is a significant risk factor for CT acquisition. A microbial risk score (MRS) further identified a network of bacterial genera associated with increased CT risk. Post treatment, the CVM associated with CT acquisition re-emerged in a different subset of cases leading to reinfection. Additionally, the analysis s

SUBMITTER: Usyk M 

PROVIDER: S-EPMC12035847 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature