Antcin K ameliorates cardiotoxin-induced skeletal muscle injury and inflammation via IL-10 regulation.

ABSTRACT: Background: Skeletal muscle, functioning as an endocrine organ, produces a variety of molecules that contribute to the pathophysiology of sarcopenia, leading to muscular injury and inflammation. Antcin K, a bioactive compound derived from Antrodia cinnamomea and used in traditional Chinese medicine for its anti-inflammatory properties, was evaluated in this study with the aim of assessing its effects on resisting the progression of sarcopenia both in vitro and in vivo. Methods: Cardiotoxin (CTX)-induced muscle injury and the treatment of Antcin K in C2C12 cells were both used for RNA sequencing and ingenuity pathway analysis. We also stably cloned an IL-10 knockdown (IL-10^-/+) C2C12 cell line for the effects of Antcin K treatment on CTX-induced

SUBMITTER: Chang TK 

PROVIDER: S-EPMC12035881 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature