Biologically active withanolides from <i>Physalis peruviana</i>.

ABSTRACT:

Context

Physalis peruviana L. (Solanaceae), also known as Poha, has been used in traditional medicine since pre-Columbian times, particularly in treating cancer.

Objective

To study the chemical composition and potential medicinal properties of Poha.

Materials and methods

The fresh fruits and aerial parts of Poha were extracted. The isolation of extract yields a novel withanolide (physaperuvin K; 1) from the edible fruit, and seven withanolides (2-8), including a rare chlorinated withanolide (physalolactone; 2) from the aerial parts. Structure elucidation/determination was performed, some acetate derivatives were prepared (2a-6a), and the compounds were evaluated with in vitro assays indicative of anti-inflammator

SUBMITTER: Sang-Ngern M 

PROVIDER: S-EPMC12035931 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature