Accelerated senescence of bone marrow erythrocyte precursors in myelodysplastic syndrome.

ABSTRACT:

Background

Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic disorders characterized by ineffective haematopoiesis, refractory cytopenia, and an increased risk of progression to acute myeloid leukaemia. This study investigates the presence of cellular senescence in bone marrow (BM) CD235a⁺ erythrocyte precursors of MDS patients and explores its correlation with anaemia.

Methods

We assessed senescence-related markers and cell cycle distribution in BM CD235a⁺ erythrocyte precursors of MDS patients. Correlation analyses were conducted between the relative mRNA expression of p16^INK4A, a key senescence regulator, and peripheral blood parameters.

Results

MDS patients exhibited heightened cellular senesce

SUBMITTER: Liu M 

PROVIDER: S-EPMC12035936 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature