Tranexamic acid is associated with post-injury mortality in a resource-limited trauma system: Findings from the epidemiology and outcomes of prolonged trauma care cohort study.

ABSTRACT:

Background

Injury-related deaths claim millions of lives annually, with severe hemorrhage a leading cause. This study assesses tranexamic acid (TXA) administered within 3 h post-injury on mortality in trauma patients.

Study design and methods

We conducted secondary database analysis of EpiC, a multicenter, prospective cohort of trauma patients in South Africa. We compared mortality between severely injured patients at risk for traumatic hemorrhage receiving TXA within 3 h post-injury versus untreated patients. Inverse probability of treatment weighting adjusted for confounders, and multivariate logistic regression assessed 24-h mortality, with extended secondary outcome analyses.

Results

Of 3607 analyzed patients, 502 received TXA within 3 h. TXA reduced 24-h mortalit

SUBMITTER: Wogu AF 

PROVIDER: S-EPMC12035990 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature