Elevated NGF provokes decidual lipid peroxidation and promotes preterm birth in mice.

ABSTRACT:

Background

Preterm birth (PTB) is a major cause of neonatal morbidity and mortality worldwide, with infection and inflammation being the most common triggers. However, many cases of preterm labor have unknown causes. The maternal decidua is a highly dynamic and heterogeneous region, serving as the nexus at the maternal-fetal interface, connecting the mother and the fetus. Increasing evidence suggests that the maternal decidua plays a crucial role in the initiation of labor. Nerve growth factor (NGF), is an important member of the neurotrophin family and is identified to play a crucial role in initiating the decidual response.

Methods

To investigate whether NGF contributes to preterm birth via lipid peroxidation-dependent pathways, we selected both NGF and erastin (a pharmaco

SUBMITTER: Ge Y 

PROVIDER: S-EPMC12036137 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature