Circulating linoleic acid and its interplay with gut microbiota during pregnancy for gestational diabetes mellitus.

ABSTRACT:

Background

Circulating linoleic acid (LA) levels have been reported to be associated with various metabolic outcomes. However, the role of LA and its interplay with gut microbiota in gestational diabetes mellitus (GDM) remains unclear. This study aimed to investigate the longitudinal association between circulating LA levels during pregnancy and the risk of GDM, and the potential role of gut microbiota.

Methods

A nested case-control study was conducted within the ongoing Tongji-Huaxi-Shuangliu Birth Cohort in Chengdu, China. Blood and fecal samples were collected during early and middle pregnancy from 807 participants. GDM was diagnosed in middle pregnancy using the International Association of Diabetes and Pregnancy Study Groups criteria. Plasma LA levels were measured usin

SUBMITTER: Qiu J 

PROVIDER: S-EPMC12036143 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature