Stable Plasmodium falciparum merozoite surface protein-1 allelic diversity despite decreasing parasitaemia in children with multiple malaria infections.

ABSTRACT:

Background

Individuals experiencing recurrent malaria infections encounter a variety of alleles with each new infection. This ongoing allelic diversity influences the development of naturally acquired immunity and it can inform vaccine efficacy. To investigate the diversity and infection variability, Plasmodium falciparum merozoite surface protein 1 (PfMSP1), a crucial protein for parasite invasion and immune response, was assessed in parasites isolated from children in the Junju cohort, Kilifi County, who experienced at least 10 febrile malaria episodes over a span of 5 years.

Methods

Pfmsp1 C-terminal region (Pfmsp1₁₉) was genotyped using PCR followed by capillary sequencing in blood samples collected from the children. Sequenced reads were trimmed and aligned t

SUBMITTER: Yaa RM 

PROVIDER: S-EPMC12036178 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature