Analysis of causal effects on metabolic syndrome and inflammatory bowel disease: a Mendelian randomization study.

ABSTRACT:

Background

Metabolic syndrome (MetS) is a conglomerate of metabolic abnormalities including hypertension, obesity, hyperglycemia, hypertriglyceridemia, and low levels of high-density lipoprotein cholesterol (HDL-C). The relationship between MetS and Inflammatory Bowel Disease (IBD) has received a lot of attention lately. Epidemiological investigation has yet to determine if the two illnesses are causally related. To investigate the causal link between IBD and MetS levels, we screened publically available genome-wide association study (GWAS) data using Mendelian randomization (MR) analysis. The study aimed to comprehensively analyze the causal association of each component of MetS, including fasting blood glucose(FBG), HDL-C, triglyceride(TG), waist circumference(WC), and hypertensi

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12036182 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature