Therapeutic potential of GLP-1RAs in sleep apnea with genetic associations to type 2 diabetes.

ABSTRACT:

Background

Some observational studies found that there is an epidemiological association between type 2 diabetes (T2D) and sleep apnea (SA) and glucose-lowering drugs may lower SA risk. However, the causative relationship among them remains unclear.

Methods

Linkage Disequilibrium Score Regression (LDSC) was utilized to assess the genetic correlation between T2D and SA. Mendelian Randomization (MR) was applied, primarily using the inverse variance weighted (IVW) method, to evaluate the causal relationship between T2D and SA. Additionally, we performed Drug-target MR analysis to evaluate the impact of Glucagon-like Peptide-1 Receptor Agonists (GLP-1RAs) on SA. We used two kinds of genetic instruments to proxy the exposure of GLP-1RAs, including expression quantitative trait lo

SUBMITTER: Cheng F 

PROVIDER: S-EPMC12036185 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature