Self-healing adhesive oxidized guar gum hydrogel loaded with mesenchymal stem cell exosomes for corneal wound healing.

ABSTRACT: Hydrogels have shown great potential and value in wound healing. In this study, we construct a mesenchymal stem cell exosomes (MSC-Exos) laden natural biopolymer-based hydrogel with transparent, self-healing, injectable, and tissue adhesive properties to promote corneal regeneration. This hydrogel is synthesized by combining aldehyde-modified oxidized guar gum (OGG) and carboxymethyl chitosan (CMCS) through the dynamic, reversible Schiff base bonds, which endow it with outstanding shear-thinning and self-healing properties, facilitating easy injection through a needle. The physicochemical properties, such as porosity, mechanical strength, and light transmittance, could be precisely tunable by adjusting OGG concentrations. The resultant hydrogel achieves robust tissue adhesion at physiologi

SUBMITTER: Wei R 

PROVIDER: S-EPMC12036215 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature