Time dependent predictors of cardiac inflammatory adverse events in cancer patients receiving immune checkpoint inhibitors.

ABSTRACT:

Background

Cardio-inflammatory immune related adverse events (irAEs) while receiving immune checkpoint inhibitor (ICI) therapy are particularly consequential due to their associations with poorer treatment outcomes. Evaluation of predictive factors of these serious irAEs with a time dependent approach allows better understanding of patients most at risk.

Objective

To identify different elements of patient data that are significant predictors of early and late-onset or delayed cardio-inflammatory irAEs through various predictive modeling strategies.

Methods

A cohort of patients receiving ICI therapy from January 1, 2010 to May 1, 2022 was identified from TriNetX meeting inclusion/exclusion criteria. Patient data collected included occurrence of early and later cardio-i

SUBMITTER: Sayer M 

PROVIDER: S-EPMC12036232 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature