FastQTLmapping: an ultra-fast and memory efficient package for mQTL-like analysis.

ABSTRACT:

Background

FastQTLmapping addresses the need for an ultra-fast and memory-efficient solver capable of handling exhaustive multiple regression analysis with a vast number of dependent and explanatory variables, including covariates. This challenge is especially pronounced in methylation quantitative trait loci (mQTL)-like analysis, which typically involves high-dimensional genetic and epigenetic data.

Results

FastQTLmapping is a precompiled C++ software solution accelerated by Intel MKL and GSL, freely available at https://github.com/Fun-Gene/fastQTLmapping . Compared to state-of-the-art methods (MatrixEQTL, FastQTL, and TensorQTL), fastQTLmapping demonstrated an order of magnitude speed improvement, coupled with a marked reduction in peak memory usage. In a large dataset con

SUBMITTER: Gao X 

PROVIDER: S-EPMC12036243 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature