DNA methylation signatures of severe RSV infection in infants: evidence from non-invasive saliva samples.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) poses significant morbidity and mortality risks in childhood, particularly for previously healthy infants admitted to hospitals lacking predisposing risk factors for severe disease. This study aimed to investigate the role of the host epigenome in RSV infection severity using non-invasive buccal swabs from sixteen hospitalized infants admitted to the hospital for RSV infection. Eight patients had severe symptoms, and eight had mild to moderate symptoms. For DNA methylation analyses, the Illumina EPIC BeadChip was used with DNA isolated from saliva samples. To evaluate the basal DNA methylation level of the identified biomarkers a cohort of healthy control children was used. Furthermore, DNA methylation levels of candidate genes were conf

SUBMITTER: Pischedda S 

PROVIDER: S-EPMC12036262 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature