LAMA4⁺ CD90⁺ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8⁺ T cell senescence.

ABSTRACT: Despite significant advances in cancer biology research and treatment, clinical outcomes for patients with liver cancer remain unsatisfactory. The biological and molecular mechanisms underlying the bidirectional signaling between tumor cells and the tumor microenvironment (TME), which promotes tumor progression in the liver, remain to be elucidated. Fibroblasts are crucial regulators of tumor progression and response to therapy; however, our understanding of their roles remains limited. Here, we integrated single-cell RNA sequencing and spatial transcriptomic data of pan-liver cancers to characterize the different subtypes of cancer-associated fibroblasts (CAFs). siRNA transfection was used for knockdown the expression of LAMA4. Western blot assay was used for gene expression analysis. Flo

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12036274 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature