TPX2 promotes papillary renal cell carcinoma progression by forming a ceRNA with LINC00894.

ABSTRACT:

Purpose

Papillary renal cell carcinoma (pRCC), particularly type 2, is associated with a poor prognosis. This study aimed to identify molecular mechanisms underlying pRCC progression and explore potential therapeutic targets to improve patient outcomes.

Methods

TPX2 expression was analyzed in tumor samples from patients with type 2 pRCC. In vitro experiments were conducted to assess the effects of TPX2 and LINC00894 knockdown and overexpression on the proliferation and migration of Caki-2 and ACHN cells. Immunohistochemical analysis of tissue microarrays was performed to evaluate the associations between TPX2 expression and clinicopathological characteristics in type 2 pRCC patients.

Results

Elevated TPX2 expression was significantly associated with a worse prognosis

SUBMITTER: Ding Z 

PROVIDER: S-EPMC12036302 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature