Protective effect of antidiabetic drugs against male infertility: evidence from Mendelian randomization.

ABSTRACT:

Background

The global prevalence of diabetes has been steadily increasing, with a growing number of younger individuals being affected. Over recent decades, various antidiabetic drugs have been repurposed for treating conditions beyond diabetes. However, the effects of antidiabetic drugs on male infertility (MIF) remain inadequately elucidated. This Mendelian randomization (MR) study aims to clarify the potential impact of antidiabetic drugs on the risk of MIF.

Method

We designed a comprehensive analytical workflow involving two-sample MR and summary-based MR (SMR) to assess the causal relationship between antidiabetic drug targets and MIF. First, instrumental variables were obtained based on HbA1c levels and gene expression levels. Then, MR analysis was performed after sele

SUBMITTER: Li Y 

PROVIDER: S-EPMC12036310 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature