Explore potential immune-related targets of leeches in the treatment of type 2 diabetes based on network pharmacology and machine learning.

ABSTRACT:

Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that poses a significant global health burden due to its profound effects on systemic physiological homeostasis. Without timely intervention, the disease can progress insidiously, leading to multisystem complications such as cardiovascular, renal, and neuropathic pathologies. Consequently, pharmacological intervention becomes crucial in managing the condition. Leeches have been traditionally used in Chinese medicine for their potential to inhibit the progression of T2DM and its associated complications; however, the specific mechanisms underlying their action and target pathways remain poorly understood. The objective of this study was to predict potential therapeutic targets of leeches in the treatment of

SUBMITTER: Hu T 

PROVIDER: S-EPMC12036332 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature