Predicting Genetic Risk for Impulsivity and Substance Use in Adolescence.

ABSTRACT: Studying genetic contributions to substance initiation is crucial for identifying at-risk individuals and developing targeted prevention strategies. Investigating these factors during adolescence is vital, as this period is critical for brain development and represents an age of experimentation and initiation of substance use. Here we generate polygenic scores (PGSs), using data from the PGS catalog, across a range of substance use related traits to assess PGS in predicting i) measures of impulsivity taken from the UPPS-P questionnaire and ii) self-reported use of nicotine/tobacco, cannabis, alcohol and caffeine in early-mid adolescence. Repeat cross-sectional analyses across age bands (ages 9-10, 11-13, and 13-15) were conducted using the longitudinal Adolescent Brain Cognitive Developmen

SUBMITTER: Wade NE 

PROVIDER: S-EPMC12036370 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature