Cytokine Profiling of Children, Adolescents, and Young Adults Newly Diagnosed with Sarcomas Demonstrates a Role for IL-1β in Osteosarcoma Metastasis.

ABSTRACT:

Background

Sarcomas are a heterogeneous group of mesenchymal tumors frequently diagnosed in pediatric and young adult patients. These tumors respond poorly to conventional immunotherapy, though the precise reason for this is not known. We sought to characterize the systemic immune response to sarcomas by measuring the levels of circulating cytokines in the plasma of sarcoma patients, testing the hypothesis that the natures of a patient's immune response to their tumor directly affects outcome.

Methods

Plasma was collected from newly diagnosed, treatment-naive pediatric sarcoma patients participating in an ongoing clinical trial, MCC20320. A panel of 18 cytokines was selected and cytokine levels were measured using the Luminex platform. Cytokine levels were analyzed based on

SUBMITTER: Kastner L 

PROVIDER: S-EPMC12036375 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature