Performance of Universal and Stratified Computer-Aided Detection Thresholds for Chest X-Ray-Based Tuberculosis Screening: A Cross-Sectional Diagnostic Accuracy Study.

ABSTRACT:

Background

Computer-aided detection (CAD) software analyzes chest X-rays for features suggestive of tuberculosis (TB) and provides a numeric abnormality score. However, estimates of CAD accuracy for TB screening are hindered by the lack of confirmatory data among people with lower X-ray scores, including those without symptoms. Additionally, the appropriate X-ray score thresholds for obtaining further testing may vary according to population and client characteristics.

Methods

We screened for TB in Ugandan individuals aged ≥15 years using portable chest X-rays with CAD (qXR v3). Participants were offered screening regardless of their symptoms. Those with X-ray scores above a threshold of 0.1 (range, 0 - 1) were asked to provide sputum for Xpert Ultra testing. We estimated th

SUBMITTER: Sung J 

PROVIDER: S-EPMC12036410 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature