A pathological phosphorylation pattern enhances tau cooperativity on microtubules and facilitates tau filament assembly.

ABSTRACT: Phosphorylation plays a crucial role in both normal and disease processes involving the microtubule-associated protein tau. Physiologically, phosphorylation regulates tau's subcellular localization within neurons and is involved in fetal development and animal hibernation. However, abnormal phosphorylation of tau is linked to the formation of neurofibrillary tangles (NFTs) in various human tauopathies. Interestingly, the patterns of tau phosphorylation are similar in both normal and abnormal processes, leaving unclear whether phosphorylated tau retains its functional role in normal processes. The relationship between tau phosphorylation and NFT assembly in tauopathies is also still debated. To address these questions, we investigated the effects of tau phosphorylation on microtubule bindin

SUBMITTER: Fan X 

PROVIDER: S-EPMC12036459 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature